Hypoxic-ischemic syndrome

[Hypoxic-ischemic syndrome]

OBJECTIVE: To review the literature on the hypoxic-ischemic syndrome, emphasizing its physiopathology, clinical manifestations, and treatment. SOURCES: Electronic search in the Medline and LILACS databases, with selection of the most relevant articles. SUMMARY OF THE FINDINGS: The hypoxic-ischemic syndrome is a multisystem disease with generalized manifestations. The physiopathology is based on...

Stem Cell Therapy in Hypoxic Ischemic Encephalopathy

Introduction there are one million deaths from asphyxia in newborn annually. Management of this newborn is only supportive. Autologuse stem cell therapy may reduce mortality and long term morbidity. Outcome of asphyxiated newborn is related to damage CNS cells. Stem cells prevent Apoptosis and induce repairmen of injured neurons. Methods in a review study all article related to three keyword...

Perinatal Hypoxic-Ischemic Encephalopathy

Perinatal hypoxic-ischemic encephalopathy (HIE) is an important cause of brain injury in the newborn and can result in long-term devastating consequences. Perinatal hypoxia is a vital cause of long-term neurologic complications varying from mild behavioural deficits to severe seizure, mental retardation, and/or cerebral palsy in the newborn. In the mammalian developing brain, ongoing research i...

Perinatal Hypoxic-Ischemic Disease

Hypoxic-Ischemic Encephalopathy Biomarkers

Background Clinical RS for HIE are intended to determine trial entry and to compare groups within or between trials. Categorical current schemes do not reflect the broad clinical continuum spectrum of HIE and they were not design for this task. Objective To prospectively validate a new structured multi-item RS for HIE. Methods A standardised structured ordinal RS for HIE with 7 clinical items (...